Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.
The interferon-induced us polo assn mens sweaters dynamin-like MxA GTPase restricts the replication of influenza A viruses.We identified adaptive mutations in the nucleoprotein (NP) of pandemic strains A/Brevig Mission/1/1918 (1918) and A/Hamburg/4/2009 (pH1N1) that confer MxA resistance.These resistance-associated amino acids in NP differ between